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We have previously characterized several notable benefits through this work, including improved left ventricular performance, increased coronary perfusion to the ischemic myocardial region, diminished apoptotic death of ischemic myocytes, and reduced interstitial and perivascular fibrosis within the perfusion-restricted territory
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Notably, mutations in TP53 not only change its conformation but also cause p53 aggregation, and p53 aggregation in cells is more consequential than conformational changes
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